I watch this thing about hoarders sometimes. Its a form of anxiety-like the opposite of OCD where they live in shit coz theve a fear of throwing anything out.. and it escalates to the point of an extreme health hazard.
Its not safe living with dog urine/poo... parasites, bacteria.. perhaps the mould is causing this depression? Or maybe her house has gotten bad from the depression..
I dont know how you can help her. Shes gotta be willing to meet you half way. Have you tried telling her she needs help and your here for her. Ask her not to shut you out that you just want to help her get better... if she refuses then im not sure what you can do
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