Smart girls will be worried about the age gap. At the age of 22, she still has a lot of growing to do before she matures into the woman she is meant to be, while he is probably just about done. She will very likely outgrow him in a couple of years.
The fact that he looks younger is just a decoy for the age gap - she may or may not be interested when she finds out how old he really is.
Yes, she probably has some issues relating to how she views herself in relationship to men, probably due to some dysfunction with her father.
Relax... I'll need some information first. Just the basic facts - can you show me where it hurts?